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  Brefeldin A [BF A] ,, [Decumbin] ,, [Ascotoxin] ,, [Cyanein]
Catalog Number
5 mg
  Certificate of Analysis
  Material Safety Data Sheet
Comments :
No animal source
Storage :

Protect from light and moisture; Store at -20oC

Analytical Data :

Exc: 203 nm in EtOH / Em: none,,Soluble in DMSO, DMF, CH3OH and CHCl3 ,,,≥99% by HPLC

Synonym :

1,6,7,8,9,11a,12,13,14,14a-Decahydro-1, 13-dihydroxy-6-methyl-4H- cyclopent[f]oxacyclotridecin-4-one

Application :

Endoplasmic Reticulum and Golgi Apparats probe.  A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis

References :

1; Beltowski J, Marciniak A, Wojcicka G. J Physiol Pharmacol 55, 391-407 (2004).-----2; Kondylis V, Rabouille C. J Cell Biol 162, 185 (2003).------3; Zhu T, Ling L, Lobie PE. J Biol Chem 277, 45592-603 (2002).------4; Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation.  Guo, H., et. al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245:  57-68 (1998).


Brefeldin A [BF A] ,, [Decumbin] ,, [Ascotoxin] ,, [Cyanein]

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