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  4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid, dipotassium salt [Bis-ANS]
Catalog Number
5 mg
  Certificate of Analysis
  Material Safety Data Sheet
Comments :
No animal source
Storage :

Protect from light and moisture; Store at 4-8oC

Analytical Data :

Exc: 395 nm / Em: 500 nm in CH3OH, soluble in DMSO, CH3OH and H2O

Synonym :

[1,1'-Binaphthalene]-5,5'-disulfonic acid, 4,4'-bis(phenylamino)-, dipotassium salt.

Application :

Bifunctional fluorescent probe for nonpolar cavities in proteins. Bis-ANS has particularly high affinity for nucleotide-binding sites of some proteins. It is also useful as a structural probe for tubulin and as an inhibitor of microtubule assembly.

References :

1; Mammalian Hsp22 is a heat-inducible small heat-shock protein with chaperone-like activity." Chowdary TK, Raman B, Ramakrishna T, Rao CM. Biochem J 381, 379-87 (2004) .----------2; Active rhodanese lacking nonessential sulfhydryl groups has increased hydrophobic exposure not observed in wild-type enzyme." Kaur Y, Ybarra J, Horowitz PM. Protein J 23, 255-61 (2004) .---------3; Pressure-Induced Fusogenic Conformation of Vesicular Stomatitis Virus Glycoprotein." Gomes AM, Pinheiro AS, Bonafe CF, Silva JL. Biochemistry 42, 5540-5546 (2003)

4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid, dipotassium salt [Bis-ANS]

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