Cell permeable fluorescent indicator of intracellular Ca2+; non-fluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca2+; lower binding affinity allows measurement of higher peaks of Ca2+ transients than with Fura-2 (Genolite's 1100)
References :
1; J.P.Y. Kao, Detection of photochemically generated calcium pulses. J. Biol. Chem.264, 8179, (1989).--------2; Koncz A, Pasztoi M, Mazan M, Fazakas F, Buzas E, Falus A, Nagy G, J Immunol 2007; 179(10):6613-9.--------3; Kamioka H, Sugawara Y, Murshid SA, Ishihara Y, Honjo T, Takano-Yamamoto T, J Bone Miner Res 2006; (21):7 1012-1021