Genolite Biotek - Our products are designed for researchers in academia, government institutions, pharmaceutics, biotech industries and drug discovery companies. Our product line includes fluorescent reagents, peptides, proteins and intermediates for further synthesis.

Fluo-2, AM *Cell permeable* *1 mM/anhydrous DMSO* *GenoSol*



1223	1 ml	121714-22-5	1129.85	C₅₁H₅₀Cl₂N₂O₂₃

Certificate of Analysis

Material Safety Data Sheet

N/A

Comments :

No animal source

Storage :

Protect from light and moisture; Store at -20^oC

Analytical Data :

Exc: 506 nm / Em: 526 nm in 0.1 M Tris buffer pH 8.0,, Soluble in DMSO, DMF, CH₃CN, EtoAc and CHCl₃

Synonym :

4-(6-Acetoxymethoxy-2,7-dichloro-3-oxo-9-xanthenyl)-4′-methyl-2,2′(ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl) ester

Application :

Cell permeable fluorescent indicator of intracellular Ca²⁺; non-fluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca²⁺; lower binding affinity allows measurement of higher peaks of Ca²⁺ transients than with Fura-2 (Genolite's 1100)

References :

1; J.P.Y. Kao, Detection of photochemically generated calcium pulses. J. Biol. Chem. 264, 8179, (1989).--------2; Koncz A, Pasztoi M, Mazan M, Fazakas F, Buzas E, Falus A, Nagy G, J Immunol 2007; 179(10):6613-9.--------3; Kamioka H, Sugawara Y, Murshid SA, Ishihara Y, Honjo T, Takano-Yamamoto T, J Bone Miner Res 2006; (21):7 1012-1021

Fluo-2, AM *Cell permeable* *1 mM/anhydrous DMSO* *GenoSol*