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22-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-23,24-bisnor-5-cholen-3b-ol [NBD cholesterol] ,, [Fluoresterol]



1204	10 mg	78949-95-8	494.63	C₂₈H₃₈N₄O₄

Certificate of Analysis

Material Safety Data Sheet

Comments :

No animal source

Storage :

Protect from light and moisture; Store at 4-8^oC

Analytical Data :

Exc: 468 nm / Em: 538 nm in CH₃OH,, Soluble in DMSO, DMF, CH₃OH and CHCl₃,,, ≥98% by HPLC and TLC

Synonym :

[Pregn-5-en-3-ol, 20-methyl-21-[(7-nitro-4-benzofurazanyl)amino]-, (3β,20S)-] ,, [Pregn-5-en-3-ol, 20-methyl-21-[(7-nitro-4-benzoxadiazol-4-yl)amino]-, (3β,20S)-]

Application :

A useful cholesteryl fluorescent probe for studying of lipid transport and lipid-protein interactions.

References :

1; NBD-cholesterol incorporation by rat macrophages and lymphocytes: a process dependent on the activation state of the cells." Portioli Silva EP, Peres CM, Roberto Mendonca J, Curi R. Cell Biochem Funct 22, 23-8 (2004).---------2; Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival." Lin M, Rikihisa Y. Infect Immun 71, 5324-31 (2003) .---------3; Exclusion of a cholesterol analog from the cholesterol-rich phase in model membranes." Loura LM, Fedorov A, Prieto M. Biochim Biophys Acta 1511, 236-243 (2001)

22-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-23,24-bisnor-5-cholen-3b-ol [NBD cholesterol] ,, [Fluoresterol]